Monday, October 28, 2013

Influenza Vaccine and Cardiovascular Risk

Here is twist on the potential benefits of influenza vaccination. As summarized in this article published in JAMA, influenza vaccination may impact cardiovascular  risk.

The authors performed a meta-analysis with 5 published and 1 unpublished randomized clinical trials of 6735 patients (mean age, 67 years; 51.3% women; 36.2% with a cardiac history; mean follow-up time, 7.9 months).

Receipt of influenza vaccine was associated with a lower risk of composite cardiovascular events (2.9% vs 4.7%; RR, 0.64 [95% CI, 0.48-0.86], P = .003) in published trials. The greatest effect was seen  in patients with more active coronary disease.

Association does not mean causality and these results must be replicated with adequately powered, prospective, multi-center trials of influenza vaccination with specific cardiac endpoints.

Decreased cardiac risk of death may be a persuasive argument for those clinic patients insistent on avoiding influenza vaccination.

I am back on the ID Consult service this week and back to a proper daily grind.

No comments:

Post a Comment