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The message is simple:
Don’t continue antibiotics beyond 72 hours in hospitalized patients unless patient has clear evidence of infection.
Antibiotics are often started when a patient is possibly infected. After three days, laboratory and radiology information is available and antibiotics should either be deescalated to a narrow-spectrum antibiotic based on culture results or discontinued if evidence of infection is no longer present.
Lessening antibiotic use decreases risk of infections with Clostridium difficile (C. difficile) or antibiotic-resistant bacteria.
Any questions?